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Infectious Disease: Hepatitis

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Total 32452 results found since Jan 2013.

SemEHR: A general-purpose semantic search system to surface semantic data from clinical notes for tailored care, trial recruitment, and clinical research*
ConclusionResults from the multiple case studies demonstrate SemEHR ’s efficiency: weeks or months of work can be done within hours or minutes in some cases. SemEHR provides a more comprehensive view of patients, bringing in more and unexpected insight compared to study-oriented bespoke IE systems. SemEHR is open source, available athttps://github.com/CogStack/SemEHR.
Source: Journal of the American Medical Informatics Association - January 19, 2018 Category: Information Technology Source Type: research

Kidney and liver organ transplantation in persons with human immunodeficiency virus: An Evidence-Based Analysis.
The objective of this analysis is to determine the effectiveness of solid organ transplantation in persons with end stage organ failure (ESOF) and human immunodeficiency virus (HIV+) CLINICAL NEED: CONDITION AND TARGET POPULATION Patients with end stage organ failure who have been unresponsive to other forms of treatment eventually require solid organ transplantation. Similar to persons who are HIV negative (HIV-), persons living with HIV infection (HIV+) are at risk for ESOF from viral (e.g. hepatitis B and C) and non-viral aetiologies (e.g. coronary artery disease, diabetes, hepatocellular carcinoma). Additionally, H...
Source: Ontario Health Technology Assessment Series - December 20, 2015 Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research

The impact electronic medical record system implementation on HCV screening and continuum of care: A systematic review.
CONCLUSIONS: EMR system utilization had a positive impact on increasing HCV screening. However, the clinical effectiveness of utilizing an EMR system to help eliminate transmission and increase HCV treatment cure rates requires further study. PMID: 33549734 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - February 10, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Active search for hepatitis C patients in Primary Care
CONCLUSIONS: Active search for patients with hepatitis C in PC together with the OSD are effective measures to detect hidden infections and to increase the number of treatments, contributing to the elimination of hepatitis C.PMID:34284593 | DOI:10.17235/reed.2021.8067/2021
Source: Revista Espanola de Enfermedades Digestivas - July 21, 2021 Category: Gastroenterology Authors: Luc ía Seoane Blanco Javier Soto S ánchez Gema Sierra Dorado Leire Parapar Álvarez Manuel Crespo S ánchez Luis S ánchez Domínguez Juan de la Vega Fern ández Source Type: research

Psychiatric treatment considerations with direct acting antivirals in hepatitis C
Conclusions: Although DAAs do not add significant neuropsychiatric risk, the potentialfor DDIs is high. Consideration of DDIs is paramount to improving medication adherence and mitigating adverse effects during HCV therapy.
Source: BMC Gastroenterology - May 14, 2013 Category: Gastroenterology Authors: Sanjeev SockalingamAlice TsengPierre GiguereDavid Wong Source Type: research

Routine childhood vaccination programme coverage, El Salvador, 2011-In search of timeliness.
Abstract While assessing immunization programmes, not only vaccination coverage is important, but also timely receipt of vaccines. We estimated both vaccination coverage and timeliness, as well as reasons for non-vaccination, and identified predictors of delayed or missed vaccination, for vaccines of the first two years of age, in El Salvador. We conducted a cluster survey among children aged 23-59 months. Caregivers were interviewed about the child immunization status and their attitudes towards immunization. Vaccination dates were obtained from children immunization cards at home or at health facilities. We refe...
Source: Vaccine - December 3, 2013 Category: Allergy & Immunology Authors: Suárez-Castaneda E, Pezzoli L, Elas M, Baltrons R, Crespin-Elías EO, Pleitez OA, de Campos MI, Danovaro-Holliday MC Tags: Vaccine Source Type: research

The search is on for a hepatitis B drug, thanks to a million dollars in NIH grants to SLU
(Saint Louis University) Two grants from the National Institutes of Health will allow Saint Louis University researchers to build on breakthroughs in understanding the hepatitis B virus and begin the search for a drug to cure -- not just halt -- the illness.
Source: EurekAlert! - Medicine and Health - March 25, 2014 Category: Global & Universal Source Type: news

Search for a cure for chronic hepatitis B infection: How close are we?
Authors: Phyo WW, Soh AY, Lim SG, Lee GH Abstract Chronic hepatitis B (CHB) remains a significant unmet medical need, with 240 million chronically infected persons worldwide. It can be controlled effectively with either nucleoside/nucleotide-based or interferon-based therapies. However, most patients receiving these therapies will relapse after treatment withdrawal. During recent years, the advances in molecular biology and immunology have enabled a better understanding of the viral-host interaction and inspired new treatment approaches to achieve either elimination of the virus from the liver or durable immune con...
Source: World Journal of Hepatology - May 30, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

The search for nucleoside/nucleotide analog inhibitors of dengue virus.
This article forms part of a symposium in Antiviral Research on flavivirus drug discovery. PMID: 26241002 [PubMed - as supplied by publisher]
Source: Antiviral Research - August 1, 2015 Category: Virology Authors: Chen YL, Yokokawa F, Shi PY Tags: Antiviral Res Source Type: research

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the "magic bullet" to kill cccDNA.
This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis". PMID: 26476376 [PubMed - as supplied by publisher]
Source: Antiviral Research - October 14, 2015 Category: Virology Authors: Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M Tags: Antiviral Res Source Type: research

Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects
Conclusions: INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia.
Source: BMC Pediatrics - November 20, 2015 Category: Pediatrics Authors: Lena GottesmanMichael Del VecchioStephen Aronoff Source Type: research

Next-Generation Sequencing of 5' Untranslated Region of Hepatitis C Virus in Search of Minor Viral Variant in a Patient Who Revealed New Genotype While on Antiviral Treatment.
In conclusion, longitudinal analysis of HCV variants, employing two independent deep sequencing methods, suggests that the transient presence of a different genotype strain in PBMC was a result of superinfection and not a selection of pre-existing minor variant. PMID: 26747069 [PubMed - as supplied by publisher]
Source: Advances in Experimental Medicine and Biology - January 16, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Search for useful biomarkers in hepatocellular carcinoma, tumor factors and background liver factors  (Review).
Search for useful biomarkers in hepatocellular carcinoma, tumor factors and background liver factors (Review). Oncol Rep. 2017 Mar 31;: Authors: Shimizu D, Inokawa Y, Sonohara F, Inaoka K, Nomoto S Abstract Hepatocarcinogenesis is a complex and multistep process that involves the accumulation of genetic and epigenetic alterations in regulatory genes. To understand the development of hepatocellular carcinoma (HCC), current research has utilized improved array technologies. The identification of cancer-related molecules could lead to the development of novel molecular targets for treatment and biomarker...
Source: Oncology Reports - April 12, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research